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Resveratrol from red wine and breast cancer



It was always said that alcohol, taken in moderation, was not so dangerous as we used to believe, indeed moderate red wine consumption has many benefits. Some of these benefits exerted by red wine were mainly due to one of the active constituents found in red grapes, namely Resveratrol.

A recent study on the subject confirms that Resveratrol, a non-flavonoid polyphenol [5] from red grapes is able to stop breast cancer cells growth.


Family: Vitaceae

Genus: Vitis

Common name: Common grape vine



The mechanism seem to be linked to Aromatase inhibitors as resveratrol found in grapes, grape juice, and red wine [3]. Those inhibitors found in grapes are able to prevent the conversion of androgens to estrogen, a factor linked to breast cancer occurrence in pre-menopausal women, acting as a selective estrogen receptor as well as a powerful natural antioxidant and anti-angiogenic.

In a clinical study on the relationship between dietary intake of resveratrol and breast cancer risk conducted between 1993 and 2003, it was established that a significant inverse association between breast cancer occurrence and resveratrol intake was observed for resveratrol from grapes but not from wine [5].



But moderate Red wine consumption is not only a natural way to prevent breast cancer, it has also been associated with other health benefits as cardioprotection, neuroprotection and an increased longevity [1].



Resveratrol from grapes, together with polyphenols, epigallocatechin-3-gallate (EGCG) from green tea, genistein from soybean, isothiocyanates, curcumin from turmeric and sulforaphane from cruciferous vegetables [2], appear to be a natural anti-cancer agent from which we can benefit. In combination with quercetin and catechin, resveratrol was also found to be able to reduce cell proliferation and to block cell cycle progression in vitro [4].

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[1] Alcohol and wine in relation to cancer and other diseases. Giacosa A, Adam-Blondon AF, Baer-Sinnott S, Barale R, Bavaresco L, Di Gaspero G, Dugo L, Ellison RC, Gerbi V, Gifford D, Janssens J, La Vecchia C, Negri E, Pezzotti M, Santi L, Santi L, Rondanelli M. Department of Surgery, University of Genoa, Monza, Italy.
[2] Epigenetic Events Associated with Breast Cancer and Their Prevention by Dietary Components Targeting the Epigenome. Khan SI, Aumsuwan P, Khan IA, Walker LA, Dasmahapatra AK. National Center for Natural Products Research, ‡Department of Pharmacognosy, and §Department of Pharmacology, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United States.
[3] Red Versus White Wine as a Nutritional Aromatase Inhibitor in Premenopausal Women.Shufelt C, Merz CN, Yang Y, Kirschner J, Polk D, Stanczyk F, Paul-Labrador M, Braunstein GD. 1 Women's Heart Center, the Cedars-Sinai Heart Institute, and Department of Medicine, Cedars-Sinai Research Institute , Cedars-Sinai Medical Center, Los Angeles, California.
[4] Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model.Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, Morell L, Washington AV, Cubano LA, Dharmawardhane SF. Department of Anatomy and Cell Biology, Universidad Central del Caribe School of Medicine, Bayamon, PR 00960, USA.
[5] Resveratrol and breast cancer risk. Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C. Unité d'épidémiologie du Cancer, Institut Universitaire de Médecine Sociale et Préventive, Bugnon 17, 1005 Lausanne, Switzerland.
[6] Pixibay image under Public Domain License CC0 1.0 Universal (CC0 1.0).