Research on Magnolia's active constituents
Named after French botanist Pierre Magnol, a French botanist considered one of the most important of the botanical explorers of his time , Magnolia is an ancient genus , that has been part of a group of many medicinal plants commonly used as traditional remedies, for reducing stress and anxiety among other uses .
Different parts of Magnolia have been used as part of traditional herbal medicines, for example, the bark and/or seed cones of the Magnolia tree have been used in traditional herbal medicines in Korea, China, and Japan .
Now other studies on this plant show that the properties exerted by some of the active constituents found in Magnolia can go even further, being the possible source of future medicines, let's see some of them. Image: See credits under ref.  below.
Common name: Houpu Magnolia, Magnolia bark
HONOKIOL and PANCREATIC CANCER STUDIES
Pancreatic cancer are one of those types of cancer on which survival rates are extremely low, mainly because this type of cancer has an asymptomatic progression and sometimes it is only found in very advanced metastatic stages for which the therapies are either not effective or not sufficient to eradicate completely this terrible illness. Image: See credits under ref.  below.
But are there other therapeutic agents able to improve this clinical outcome? Let's have a look at some of the natural therapeutic agents on which pharmaceutical companies and Oncology centers are putting their interest.
One of these natural therapeutic agents seems to be Magnolia Officinalis/Grandiflora, an oriental medicinal herb rich in Honokiol, one of its main biologically active constituents responsible for some of the health benefits exerted by this herb.
Magnolia Officinalis/Grandiflora was the subject of a study done at the Mitchell Cancer Institute from the University of South Alabama, on which it was investigated how effective Honokiol from this herb was on two pancreatic cancer cell lines, MiaPaCa and Panc1, alone and in combination with the standard chemotherapeutic drug, gemcitabine .
The results were quite a discovery, as Honokiol from Magnolia Officinalis/Grandiflora "exerted growth inhibitory effects on both the pancreatic cancer cell lines by causing cell cycle arrest at G(1) phase and induction of apoptosis".
In the same study, Honokiol also potentiating the cytotoxic effects of gemcitabine. These findings are quite a discovery as they demonstrate, for the first time, the growth inhibitory effects of honokiol in pancreatic cancer.
HONOKIOL and NON-HODGKIN LYMPHOMA STUDIES
In a recent study performed on Honokiol and how could Honokiol induce apoptosis (natural programmed cell death) on human non-Hodgkin lymphoma Raji cells, it was found that Honokiol from Magnolia Officinalis/Grandiflora significantly inhibited the growth of Raji cells in a time- and dose-dependent manner, something which raises the hopes to find drugs that will possibly make good use of this properties, hopefully soon.
HONOKIOL and MAGNOLOL in FIBROSARCOMAS STUDIES
In the same line of investigations, researchers from the Department of Hygienics, Gifu Pharmaceutical University, at Gifu, Japan, found during the investigation of the inhibitory effect of Magnolia obovata bark ethanol extracts on human fibrosarcoma HT-1080 cells invasion, how Magnolol and Honokiol inhibited the activity of MMP-9, which may have been responsible, in part, for the inhibition of tumor cell invasion .
Disclaimer: The information presented on this website is not intended to prescribe or give in any way or form medical advice, recommend or diagnose. Please read the disclaimer at the bottom of this page for more info.