Health benefits of Milk thistle
MILK THISTLE ACTIVE CONSTITUENT SILIBININ EXERTS ANTI-CANCER PROPERTIES
Silibinin, a polyphenolic flavonoid also known as silybin , is the major biologically active compound of milk thistle , a plant that has recently been the subject of many clinical trials and medical studies due to the properties it exerts and the ability of some of the active constituents found in it, as Silibinin.
Silibinin is known to be used to treat affections and ailments, being an effective chemopreventive agent in various types of cancer, suppressing cancer cell growth and inhibiting colon cancer stem-like cells .
Silibinin has also been studied for its inhibitory effects on certain types of breast cancer cells [9,10], and many other anti-neoplastic effects in a variety of in-vitro and in vivo cancer models, including skin, breast, lung, colon, bladder, prostate and kidney carcinomas . Image: See credits below under reference .
Common name: Milk thistle
In spite Silymarin and its major constituent, Silibinin, have traditionally been used for the treatment of liver diseases .
It seems that Silibinin, the standardized mixture of flavonolignans from the medical plant Silybum marianum , also known as Milk thistle, has also been the subject of study for its anti-cancer properties, some of them showed that silibinin is able to inhibit up to a certain point the human leukaemia cell line K562 .
The treatment of the K562 cells with silymarin resulted in a significant inhibition of cell growth and telomerase activity. The anticancer activity of silymarin in human leukemia K562 may lead to the development of new anti-cancer drugs using this property .
Molecular Formula: C25H22O10
Molecular Weight: 482.43618
Common names: Silymarin I, silibinin, Silliver, Silybine, Flavobin, Flavobin Spofa, Silymarine I, Silibinine, Silibininum.
SILIBININ AND PROSTATE CANCER
Silibinin is obtained from Silybin, an extract from the milk thistle plant seeds that has been shown to exert inhibitory properties against prostate tumor formation in the TRAMP model.
It seems, however, that this inhibitory property was limited to inhibition of the growth of established prostate neoplasms late in the process of tumor progression , bringing its use to a more therapeutic than chemopreventive purpose . Silibinin is an herbal compound with anti-cancer activity on prostate and colorectal cancers.
SILIBININ AND BREAST CANCER
Studies did on the cytotoxic effects of Silibinin against T47D breast cancer cells showed how this active constituent found in Milk thistle was able to inhibit the expression and the secretion of leptin, with which it may in future become a drug candidate for breast cancer therapy .
Other studies suggest also that may play an important role in the inhibition of metastasis of human breast cancer by preventing the epidermal growth factor . Additionally, silibinin-induced MCF-7 cell apoptosis, or natural cell death, on this type of human breast cancer cells .
SILIBININ AND COLON / COLORECTAL CANCER
Silibinin is also known to be an herbal compound with anti-cancer activity on prostate and colorectal cancers .
In another study on colon tumor cells (SW480) and the metastatic cells (SW620), silibinin showed its potential as the promising anti-cancer agent, being able to selectively induce apoptosis (natural programmed cell death) in cancer cells . Another reason to suggest it may well be a new chemopreventive and therapeutic agent.
SILYMARIN FROM MILK THISTLE FOR ALZHEIMER'S DISEASE
Last but not least, nature provided us with another active constituent that seems to attenuate cognitive deficits caused by the formation of senile plaques, Silymarin, a flavonoid derived from the herb milk thistle (Silybum marianum).
Silymarin from Milk thistle, used as part of traditional herbal remedies against liver diseases, has been found to be able to suppress senile plaques formation known as amyloid β-protein (Aβ) in mouse models . Silymarin has been shown to have antioxidative properties.
Silibinin (silybin), the flavonoid derived from the herb Milk thistle, has potent anti-inflammatory and antioxidant properties. Silibinin prevents memory impairment and oxidative damage induced by Abeta(25-35) and may be a potential therapeutic agent for Alzheimer's disease .
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