Curcumin and prostate cancer
LMU MUNICH DISCOVERS HOW CURCUMIN FIGHTS METASTASIS
Curcuma longa, a bitter taste tropical plant that belongs to the Zingiberaceae family cultivated extensively in Asia, India, China and many other countries , has been traditionally used in Ayurvedic medicine to treat multiple symptoms and as a natural remedy for many other ailments and affections.
Curcuma longa resembles a lot other Zingiberaceae family plants as Zingiber officinale (Ginger), and as this one has many known properties and health benefits.
The powder obtained from the dried rhizome of Curcuma longa (turmeric), known as curry, is used in many traditional Indian dishes and is part of the Indian diet since centuries ago. Image: See credits under ref.  below.
Common name: Turmeric, Curcuma longa, Curcuma domestica Valeton.
ACTIVE CONSTITUENTS IN CURCUMA LONGA
Almost everyone is familiar with the yellow colour of curry, but not everyone knows that this colour is the effect of a polyphenol found in Curcuma longa rhizome, a polyphenol known as Curcumin.
Curcumin (diferuloylmethane), one of the most active chemical constituents found in Turmeric or Curcuma longa, is a pungent, bitter and astringent turmeric constituent that has been traditionally used in herbal preparations and as a dye and flavouring agent, a polyphenol compound from the group of curcuminoids. Now scientists from Ludwig-Maximilian University in Munich (LMU) led by PD Dr Beatrice Bachmeier, have discovered that Curcumin suppresses metastases of certain cancers.
Knowing about the properties exerted by Turmeric, scientists and researchers have been targeting this plant since years ago, some of them with quite a big success in their findings of cancer, Alzheimer's disease prevention...etc.
Now scientists from Ludwig-Maximilian University in Munich (LMU) led by PD Dr Beatrice Bachmeier, have discovered how Curcumin, the polyphenol responsible for the characteristic yellow colour of curry, suppresses metastases of certain cancers .
In animal models, the team demonstrated how Curcumin was able to significantly reduce the formation of lung metastases of advanced breast cancer.
CURCUMIN AND METASTASIS
In spite the study was focused on the use of Curcumin as a preventive agent in prostate cancer metastasis, breast cancer is also driven by the same type of latent or chronic inflammatory reactions producing pro-inflammatory proteins known as cytokines. In the study, performed in animals, Curcumin was able to decrease of two of these cytokines, namely CXCL1 and CXCL2 .
CURCUMIN ANTI-INFLAMMATORY AND ANTI-CANCER PROPERTIES
But these are not the only benefits of curcumin. In other studies and experiments, curcumin exhibited very powerful anti-inflammatory properties , probably due to the effect that it has on the activities of cytokines, enzymes and transcription factors linked to inflammation, proving also its potential benefit for the treatment of cancer (Hep3B Liver and MCF-7 Breast Cancers) .
Additionally, curcumin induced apoptosis in several types of human SCLC NCI-H446 cells. Image right: Turmeric flower by foam under Creative Commons licence (CC BY 2.0).
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