Resveratrol from red grapes may prevent Alzheimer's disease
Resveratrol exert neuroprotective properties against Alzheimer's disease
Resveratrol (3,5,4'-trihydroxy-trans-stilbene), is a non-flavonoid polyphenol  naturally occurring in several foods and plants as red grapes (Vitis vinifera), where it is primarily found in the skin but also in its seeds, and also in the roots of hellebore (Veratrum album), from where it was originally isolated by Takaoka back in 1940 , and in more than other 70 plant species, among which we can mention berries and peanuts .
In spite nowadays it is widely known that resveratrol may exert many health benefits, as for example stop breast cancer cell growth, increase longevity, be cardioprotective, neuroprotective , to treat pain, inflammation, tissue injury and even beneficial against coronary heart disease , something that was only found back in 1992, it hasn't been until recently that resveratrol properties to reduce the risk of neurodegenerative diseases as Alzheimer's disease got such evidence of effectiveness.
Occurrence: Red grapes, berries, peanuts, hellebore
Now, researchers from the School of Traditional Chinese Pharmacy in Shanghai have found how resveratrol may reduce the risk of developing Alzheimer's disease, the most commonly occurring illness among elderly population characterized by a progressive dementia.
The study, performed in animal models, shows how resveratrol is able to enhance the clearance of amyloid beta-peptides, the plaques accumulated in our brains responsible for the development of Alzheimer's disease.
The study confirms the findings of other researchers [8,9] that already announced similar outcomes while studying the effects of resveratrol on multiple mechanisms in Alzheimer's disease. Others naturally occurring phytochemicals in curcumin and green tea, as the catechins found in this last one, have been suggested to play an important role on the prevention of Alzheimer's disease .
The mechanism of action seems quite simple, resveratrol promotes the non-amyloidogenic cleavage of the amyloid precursor protein, which consequently enhances the clearance of the amyloid beta-peptides and provides a neuroprotective effect that may help to prevent the occurrence of Alzheimer's disease .
 Resveratrol, a neuroprotective supplement for Alzheimer's disease. Li F, Gong Q, Dong H, Shi J. School of Traditional Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
 Alcohol and wine in relation to cancer and other diseases. Giacosa A, Adam-Blondon AF, Baer-Sinnott S, Barale R, Bavaresco L, Di Gaspero G, Dugo L, Ellison RC, Gerbi V, Gifford D, Janssens J, La Vecchia C, Negri E, Pezzotti M, Santi L, Santi L, Rondanelli M. Department of Surgery, University of Genoa, Monza, Italy.
 Epigenetic Events Associated with Breast Cancer and Their Prevention by Dietary Components Targeting the Epigenome. Khan SI, Aumsuwan P, Khan IA, Walker LA, Dasmahapatra AK. National Center for Natural Products Research, ‡Department of Pharmacognosy, and §Department of Pharmacology, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United States.
 Red Versus White Wine as a Nutritional Aromatase Inhibitor in Premenopausal Women.Shufelt C, Merz CN, Yang Y, Kirschner J, Polk D, Stanczyk F, Paul-Labrador M, Braunstein GD. 1 Women's Heart Center, the Cedars-Sinai Heart Institute, and Department of Medicine, Cedars-Sinai Research Institute , Cedars-Sinai Medical Center, Los Angeles, California.
 Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model.Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, Morell L, Washington AV, Cubano LA, Dharmawardhane SF. Department of Anatomy and Cell Biology, Universidad Central del Caribe School of Medicine, Bayamon, PR 00960, USA.
 Resveratrol and breast cancer risk. Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C. Unité d'épidémiologie du Cancer, Institut Universitaire de Médecine Sociale et Préventive, Bugnon 17, 1005 Lausanne, Switzerland.
 Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
Marambaud P, Zhao H, Davies P.
Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders, North Shore-Long Island Jewish Institute for Medical Research, Manhasset, NY 11030, USA.
 Resveratrol--a boon for treating Alzheimer's disease?
Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, 97006, USA.
 Nutritional approaches to modulate oxidative stress in Alzheimer's disease.
Pocernich CB, Lange ML, Sultana R, Butterfield DA.
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
 Naturally occurring phytochemicals for the prevention of Alzheimer's disease.
Kim J, Lee HJ, Lee KW.
Major in Biomodulation, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
 Plant names: Porcher Michel H. et al. 1995 - 2020, Sorting Vitis Names. Multilingual Multiscript Plant Name Database (M.M.P.N.D) - A Work in Progress. School of Agriculture and Food Systems. Faculty of Land & Food Resources. The University of Melbourne. Australia.
< http://www.plantnames.unimelb.edu.au/Sorting/Vitis.html > (2007).
- Tags: 3, 4'-trihydroxy-trans-stilbene, 5, A ngun, ALZHEIMER, ALZHEIMER'S DISEASE, Ambelos (plant), AMYLOID BETA-PEPTIDES, AMYLOID PRECURSOR PROTEIN, BREAST CANCER, BREAST CANCER AND RESVERATROL, BREAST CANCER CELL GROWTH, BREAST CARCINOMA, Budou, BULGARIAN: Вино Vino, BULGARIAN: Вино Vino, CARDIOPROTECTIVE, CHINESE: 歐 洲葡萄, CORONARY HEART DISEASE, DANISH: Almindelig vin, DANISH: Almindelig vin, ENGLISH: Cultivated winegrape, ENGLISH: Common grapevine, ENGLISH: Cultivated winegrape, ENGLISH: Wild grape, European grape, FINNISH: Viiniköynnös, FINNISH: Viiniköynnös, FRENCH: Lambrusque, FRENCH: Vigne, FRENCH: Lambrusque, GERMAN: Echter Weinstock, GERMAN: Weinrebe, GERMAN: Wild-Rebe, Grape, Grapevine, GREEK: Αμπέλι Ambeli, GREEK: Αμπέλι Ambeli, INCREASE LONGEVITY, INFLAMMATION, ITALIAN: Ambrusca, ITALIAN: Labrusca, ITALIAN: Lambrusca, JAPANESE: ヤセイヨーロッパブドウ, JAPANESE: ヨーロッパブドウ, Klima (plant), Kλήμα, Kλήμα Klima (plant), Lambrusca, Lebrusca, NEURODEGENERATIVE, NEURODEGENERATIVE DISEASE, NEUROPROTECTIVE, NON-AMYLOIDOGENIC CLEAVAGE, Obyknobennaia vinogradnaia, Ou zhou pu tao, PAIN, PORTUGUESE: Videira selvagem, PORTUGUESE: Uva (Brazil), PORTUGUESE: Videira selvagem, PORTUGUESE: Vinho, Rebe, Rebstock, RESVERATROL, RUSSIAN: Виноград культурный, RUSSIAN: Обыкновенная виноградная Obyknobennaia vinogradnaia, RUSSIAN: Виноград культурный, RUSSIAN: Виноград лесной, RUSSIAN: Обыкновенная виноградная, sativa Beger, SPANISH: Parra, SPANISH: Vino, Stafyli (fruit), Stafylia, SWEDISH: Vindruva, SWEDISH: Vinranka, sWEDISH: Vindruva, SWEDISH: Vinranka, THAI: องุ่น, TISSUE INJURY, Vid, Vid común, Videira (Brazil), Videira-europeia, Vigne, Vigne commune, Vigne cultivée, Vigne sauvage, Vigne vinifère, Vigne vinifère_ GERMAN: Weinrebe, Vin, Vine, Vinha, Vinho, Vino, Vinograd kul'turnyi, Vinograd lesnoi, Vinranke, Vinstok, Vite, Vite selvatica, Vite coltivata, Vite comune, Vite selvatica, Vitis laciniosa, VITIS LACINOSA, Vitis mediterranea, Vitis mediterranea Andrasov, Vitis sylvestri, Vitis sylvestris, Vitis vinifera, Vitis vinifera DC_, Vitis vinifera L_ subsp_ sativa Beger, Vitis vinifera sativa, Vitis vinifera sylvestris, Wein, Wein-Rebe, Weinrebe, Weinstock, Wine grape, Yasei yooroppu budou, Yooroppu budou, Zampino, Άμπελος, Άμπελος Ambelos (plant), β-AMYLOID PEPTIDE, Σταφύλι, Σταφύλι Stafyli (fruit), Σταφύλια, Σταφύλια Stafylia, Виноград Vinograd, Виноград культурный, Виноград культурный Vinograd kul'turnyi, ブドウ