BAICALEIN
Baicalein is a phenolic flavonoid compound [3,13], a flavone extracted from the roots of Scutellaria baicalensis [13], Scutellaria paniples and Oroxylum indicum. Phenolic compounds are the largest group of plants secondary metabolites [4]. They are known for their many beneficial properties and health-promoting characteristics, most of those mainly exerted by its antioxidant and free-radical scavenging distinctive properties. Polyphenolic compounds have also reported an anti-ulcerogenic activity and a good level of gastric protection [4].
Baicalein protects the cells against oxidative stress. Polyphenols are also known to contribute to the prevention of cardiovascular diseases, cancer, osteoporosis, neurodegenerative diseases as Alzheimer's disease and dementia, also as anti-influenza viral agent [8], and diabetes mellitus [4] among many others. Let's see how some of these properties.
CHEMICAL FORMULA
5,6,7-trihydroxyflavone
ARTICLES ON BAICALEIN
REFERENCES
[1] Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells.
Wu B, Li J, Huang D, Wang W, Chen Y, Liao Y, Tang X, Xie H, Tang F.
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, P,R, China.
[2] Polyphenols and Neuroprotection against Ischemia and Neurodegeneration.
Lin B.
Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA
[3] Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects.
Kang KA, Zhang R, Piao MJ, Chae S, Kim HS, Park JH, Jung KS, Hyun JW.
School of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju, Korea.
[4] Role of phenolic compounds in peptic ulcer: An overview.
Sumbul S, Ahmad MA, Mohd A, Mohd A.
Department of Ilmul Advia (Pharmacology), Faculty of Unani Medicine, Hamdard University, New Delhi, India.
[5] Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects.
Kang KA, Zhang R, Piao MJ, Chae S, Kim HS, Park JH, Jung KS, Hyun JW.
School of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju, Korea.
[6] Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade.
Xiong Z, Jiang B, Wu PF, Tian J, Shi LL, Gu J, Hu ZL, Fu H, Wang F, Chen JG.
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
[7] Mechanistic study of the structure-activity relationship for the free radical scavenging activity of baicalein.
Marković ZS, Dimitrić Marković JM, Milenković D, Filipović N.
Department of Biochemical and Medical Sciences, State University of Novi Pazar, Vuka Karadžića bb, Novi Pazar 36300, Republic of Serbia
[7] Baicalein significantly protects human retinal pigment epithelium cells against H₂O₂-induced oxidative stress by scavenging reactive oxygen species and downregulating the expression of matrix metalloproteinase-9 and vascular endothelial growth factor.
Liu JH, Wann H, Chen MM, Pan WH, Chen YC, Liu CM, Yeh MY, Tsai SK, Young MS, Chuang HY, Chao FP, Chao HM.
Department of Ophthalmology, Cheng Hsin General Hospital , Taipei, Taiwan, Republic of China.
[8] Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serum.
Xu G, Dou J, Zhang L, Guo Q, Zhou C.
School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, P. R. China.
[9] The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells.
Zhou QM, Wang S, Zhang H, Lu YY, Wang XF, Motoo Y, Su SB.
Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
[10] Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood.
Romanouskaya TV, Grinev VV.
Belarussian State University, Minsk, Belarussia.
[11] Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells.
Wang CZ, Li XL, Wang QF, Mehendale SR, Yuan CS.
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.
[12] Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase.
Chou DS, Hsiao G, Lai YA, Tsai YJ, Sheu JR.
Department of Pharmacology, Taipei Medical University, Taipei, Taiwan.
[13] Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro.
Mu X, He G, Cheng Y, Li X, Xu B, Du G.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
[14] Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells.
Chen CH, Huang TS, Wong CH, Hong CL, Tsai YH, Liang CC, Lu FJ, Chang WH.
Graduate Institute of Biomedical and Biopharmaceutical Sciences, College of Life Sciences, National Chiayi University, 300 Syuefu Road, Chiayi 600, Taiwan.
[15] Baicalein induces apoptosis in SCC-4 human tongue cancer cells via a Ca2+-dependent mitochondrial pathway.
Lin YT, Yang JS, Lin HJ, Tan TW, Tang NY, Chaing JH, Chang YH, Lu HF, Chung JG.
Department of Nursing and Management, Jen-Teh Junior College of Medicine, Taiwan, ROC.
[16] Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effects.
Mehendale S, Aung H, Wang CZ, Tong R, Foo A, Xie JT, Yuan CS.
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.
[17] Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats.
Liu C, Wu J, Gu J, Xiong Z, Wang F, Wang J, Wang W, Chen J.
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
[18] Studies on the constituents of roots of Scutellaria planipes.
Zhang YY, Guo YZ, Ageta H, Harigaya Y, Onda M, Hashimoto K, Ikeya Y, Okada M, Maruno M.
Shenyang Pharmaceutical University, Shenyang 110015, China.
